Venue: Santiago Bernabeu.
Real Madrid are unbeaten in 13 La Liga home games (W9, D4).
They have scored 24 goals in La Liga this season (the most in the league) and have conceded 11 times (the most for teams currently in the top four).
They have failed to score only once in the 12 competitive games played this season.
Osasuna have scored 14 and conceded 13 goals in the league this season.
They have won all of their away games in La Liga this season-four wins.
Head to head
In the last 23 head-to-head encounters between the two sides, Real Madrid have won 17 games, lost two and drawn four.
The home team are unbeaten against the visitors in nine consecutive games.
Latest Performances in all competitions
Real Madrid: W-W-L-L-D
Real Madrid defeats Barcelona 2-1 in the El Clasico on Sunday to maintain their place close to the top of the La Liga table.
Carlo Ancelloti’s side are sitting in second place, one point behind Real Sociedad having played a game less. They will now look to get the top spot by taking all three points in this encounter with Osasuna.
Los Blancos have a good home record having not lost in La Liga in 13 games.
If they win this game, they will better the tally they held after ten league games in their most recent title-winning campaign (2019/20) by four points.
They look well placed to win though, given their record against the visitors who have lost their last 12 games at the Bernabeu.
Meanwhile, Welsh winger Gareth Bale, Dani Ceballos, Isco, Luka Jovic, and Uruguayan midfielder Federico Valverde are all unavailable for selection through injuries.
Possible Real Madrid starting line-ups
Thibaut Courtois, Lucas Vazquez, Eder Militao, David Alaba, Ferland Mendy, Luka Modric, Eduardo Camavinga, Toni Kroos, Marco Asensio, Karim Benzema, Eden Hazard.
Osasuna snatched a 1-1 with Granada last time out to ensure that they remain in the hunt for a place in Europe at the end of the season.
The visitors are sitting in sixth place, having won five out of their ten opening La Liga games (D3, L2).
Their aim for this game will be to pick up at least a point to push themselves into the top four places.
The possibility of doing so is high, judging by their league form as they enter this tie with three wins from their last four games (D1).
Meanwhile, Jagoba Arrasate will be without the injured trio of Ante Budimir, Jonas Ramalho and Ariadne Hernández, while left-back Jose Angel is suspended.
Possible Osasuna starting line-ups
Sergio Herrera, Nacho Vidal, Unai Garcia, David Garcia, Juan Cruz, Lucas Torro, Roberto Torres, Jon Moncayola, Darko Brasanac, Javi Martinez, Chimy Avila.
Both Real Madrid and Osasuna are entering this with something to play for.
Real Madrid wants to regain the top spot while Osasuna will want to get into the Champions League places. Such high stakes set up this match to be entertaining and difficult to predict.