The Argentine international has tested negative but he will still be quarantined and he is set to miss the Brighton match.
Manchester City have had quite a few quarantine cases this season with the likes of Kyle Walker and Benjamin Mendy isolated earlier in the season after breaking the covert protocols.
Guardiola said: “Quarantine, isolated – the rules. After nine or 10 days he will be back.
“He’s going to lose some training sessions and will need a little more time. Of course, he’s a guy who needs training to be in his best condition, especially with his knee, and this is the only bad thing.
“But the important news is that the last 10 or 15 days before being isolated he was perfect. He reacted good and this is the best news.
“At the end [of the day] we are [only] in January and the best part of the season is coming, and hopefully, we can have him.”
Meanwhile, Manchester City are closely monitoring Sergio Ramos and they could move to sign the Real Madrid defender at the end of this season.
The Spanish international will be a free agent in the summer and Pep Guardiola wants to bring the 34-year-old to Etihad.
Ramos is a world-class player and his incredible leadership qualities would be invaluable at Manchester City if he joins the club.
The Premier League side have been linked with a move for the 17-year-old Dario Sarmiento.
The youngster has been dubbed as the ‘mini Messi’ in Argentina and Manchester City are hoping to sign him when he turns 18.
The Premier League side have been negotiating with Estudiantes since the middle of last year and they are hoping to snap up the youngster in March.