Midfielder Bryan Cristante gave the hosts their lead eight minutes before the break and Stephan El Shaarawy came up with a 91st-minute winner.
Here at Anytime football, we look at the three major talking points from tonight’s contest.
Perfect start for Roma
The Italian outfit appointed Jose Mourinho as their manager with the hope of getting back to the top of Italian football and the Portuguese has made a perfect start with them so far.
Roma have won all three league matches and their level on points at the top of the table with AC Milan and Napoli.
It remains to be seen whether they can build on this start and establish themselves as a key cog in the title race this season.
Wild celebrations from Jose Mourinho
It was the Portuguese’s 1000th game of his managerial career.
Prior to the match, the Roma manager said to the team that reaching the milestone was not as important for him.
However, he admitted after the game that he had an incredible fear of losing such an iconic match and the dramatic late winner from Stephan El Shaarawy left him running down the touchline feeling he was 12 years old and not 58.
Mourinho recreated his famous touchline sprint to join the players and celebrate in front of the jubilant Roma fans.
Sassuolo’s late goal
The visitors almost handed Jose Mourinho a massive heartbreak with their goal in the 96th minute but it was overturned for offside.
Stephan El Shaarawy’s dramatic winner left Roma bagging the three points at home and Mourinho will be incredibly proud of his side for the start they have made to the league campaign this season.