The official website of the Dutch national team has confirmed that manager Frank de Boer is unlikely to call up a replacement for the central midfielder, and Holland are set to make do with the options at their disposal.
It has been a devastating season for Van de Beek, both at the club and international level.
The details of his injury have not been released yet, and it will be interesting to see if the player can recover in time and join up with his club for the pre-season.
The pre-season with Manchester United will be extremely crucial for van de Beek as he aims to establish himself as a key player for Ole Gunnar Solskjaer next season.
A player of his calibre needs to play regularly, and if he cannot get that opportunity at Old Trafford, he should seriously consider leaving this summer for his own good.
Meanwhile, Holland will play their first group game of the European Championships against Ukraine on the 13th of June, and they will be hoping to have a successful tournament in the summer.
De Boer has quality midfield options in the form of Frenkie de Jong, Gini Wijnaldum, Ryan Gravenberch and Teun Koopmeiners at their disposal. They should be able to cope with the loss of van de Beek heading into the Euros.